Larger Fat Cells Linked to How the Body Handles Fat After Meals
Professor André Carpentier's team found that, regardless of body fat, people with larger belly fat cells took more fat into the heart after meals and stored more in deep belly fat.
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iScience
Features based on peer-reviewed papers published in iScience.
Switching Off Chronic Pain
Dr. Philip Cornish's team reports that placing implanted neuromodulation electrodes with a physics-based framework was strongly linked to patients reporting complete relief from chronic pain, in a retrospective study.
This Strange Protein Could Be the Key to Cell Communication
Dr. Oktay Kaplan's team found that the protein ARL13B keeps paired cilia on worm sensory neurons growing side by side, apparently by regulating the cilia membrane rather than cilia length.
Engineers Create Instant Solution for Controlling Light and Energy
Professor Tie Jun Cui's team built a physics-driven deep learning model that works out programmable metasurface coding patterns almost instantly, without large labelled training datasets, to steer electromagnetic beams.
Overactive brain signals disrupt light sensitivity in autism-related disorder
Dr. Justyna Zmorzynska's team found that an overactive growth pathway in zebrafish modelling tuberous sclerosis disrupts light-processing neurons and light preference, which the drug rapamycin restored.
HDAC inhibitors target crucial oncogene and tumor immune microenvironment in TNBC
Dr. Rumela Chakrabarti's team found that the protein ΔNp63 helps triple-negative breast cancer suppress immunity in mice, and the HDAC inhibitor Quisinostat lowered it, slowing tumour growth and spread.
The Heightened COVID-19 Threat for People Living with HIV
Professor Giulia Marchetti's team found that unvaccinated people with HIV hospitalised with COVID-19 had more virus in their blood, skewed T-cell responses and stronger inflammation than others.
Revamping cancer vaccines: time to think differently
Dr. Moutih Rafei's team found that treating mesenchymal stromal cells with an Accum variant turned them into antigen-presenting cells that triggered strong anti-tumour responses in mice.
ALS Under the Microscope: Immune Cells, Genetics, and the Quest for Answers
Dr. Okiru Komine and Professor Koji Yamanaka's team found that genetic background alters microglia subtypes, immune cell infiltration and disease progression in ALS model mice of different strains.
Harnessing Electricity to Convert CO2 into Valuable Resources
Dr. Ke Xie and colleagues set out principles for designing molecular catalysts that use electricity to turn carbon dioxide into fuels and chemicals more efficiently and selectively.
The Battle of the Nest: Evolution’s Answer to Egg Survival
Dr. Analía López's team found that brood parasitic birds build tougher eggshells through more complex crystal grain boundaries in the outer shell layer, not through thickness alone.
The Hidden Trigger: Brain Cell Stress as a Key to Solving Parkinson’s
Dr. Tomoki Kuwahara's team found that lysosomal stress drives immune cells of the macrophage lineage to release harmful α-synuclein through the LRRK2-Rab10 pathway.
Messages from cells: breaking new ground in deciphering protein behaviour
Dr. Elisabetta Mileo and Professor Barbara Zambelli's teams found that the bacterial nickel-delivery protein UreG stays flexible inside living cells, shifting between loose and compact shapes.
Iron Unlocked: Paving the Way for Affordable Green Hydrogen
Dr. Maximilian Demnitz's team found that adding iron to the electrolyte of alkaline water electrolysis acts as a catalyst, making hydrogen production more efficient without scarce materials or complex catalyst designs.
Innovative Study Reveals neo-functionalization of TLR7 in pisciformes
Professor Jianguo Su's team found that fish TLR7, an immune sensor, has evolved to detect double-stranded as well as single-stranded viral genetic material, triggering antiviral and antibacterial defences.
The Dawn of Enhanced Particle Control with Optical Vortex Technology
Francisco Muñoz-Pérez's team designed a multiplexed spiral phase mask that creates concentric optical vortices, letting optical tweezers trap several microparticles and send each orbiting independently.
Aurora B Kinase A Key to Understanding Human Reproduction
Professor Juan Jimenez's team found in fission yeast that Aurora B kinase resets chromosome-microtubule attachments between the two meiotic divisions, ensuring sister chromatids separate correctly.
New Study Sheds Light on Breast Cancer’s Genetic Drivers
Professor Wei Gu's team found that the long noncoding RNA MACC1-AS1 partners with the protein DDX5 to switch on MACC1, a gene linked to cancer spread, in breast cancer cells.
How TM4SF5 Influences Eating Habits and Chronic Liver Disease
Professor Jung Weon Lee's team found that mice with extra liver TM4SF5 ate more during rest periods and developed fatty liver features linked to the appetite hormone apelin.
Groundbreaking Discovery in Liver Health with 15-keto-PGE2
Professor Lee-Ming Chuang's team found that an anti-inflammatory compound blocks a key inflammatory switch in immune cells and reduced liver inflammation and damage in mice with fatty liver disease.