Clinical studies, public health, pharmacology and the biology of disease.
Professor Lee-Ming Chuang's team found that an anti-inflammatory compound blocks a key inflammatory switch in immune cells and reduced liver inflammation and damage in mice with fatty liver disease.
Dr. Surachat Jaroonpipatkul's team reports a man with gout whose swollen pacemaker pocket held clotted blood and uric acid crystals, a rare complication outside the joints.
Professor Jonathan Smith's team found that a common atrial fibrillation risk variant lowers activity of the FAM13B gene, altering heart cells' electrical signalling and calcium handling.
In a placebo-controlled study led by Dr. Jason Bush, healthy adults taking resistant potato starch had lower blood histamine, with signs pointing to a stronger gut barrier.
Dr. Benjamin Djulbegovic and Dr. Charles Greenberg argue that unnecessary referrals to haematologists, driven partly by time pressure, fragment care and lengthen waits for patients.
Dr. Diana Chinchilla's team analysed Leptospira genomes and found that Leptospira santarosai, a cause of leptospirosis, occurs mainly in the Americas and splits into many location-linked genetic groups.
Dr. Francesca Cavallo and Professor Christofer Toumazou designed a recommender app that tailors activity advice to each user's diabetes cluster, and simulations on UK Biobank data suggest it could raise activity.
Dr. William Thomson and colleagues review how pandemics have shaped critical care and argue that coordination, adaptable trials and continuous learning are central to pandemic readiness.
Dr. Laura Maria Horga and Professor Alister Hart's team used high-resolution MRI to show that symptom-free long-distance runners had no more major hip damage than non-runners.
Dr. Jungsun Kim's review describes how reprogramming cancer cells towards a stem-cell-like state, then back towards cancer, offers a model for studying epigenetic changes as tumours progress.
Professor Robert Wolfe's review weighs the main tracer methods for measuring how the whole body builds and breaks down protein after eating, setting out each method's strengths and limits.
Professor Heather Brenhouse's team found that early separation followed by social isolation had sex-specific effects on anxiety-like behaviour in rats, and compounded damage to prefrontal brain structure in females.
