Clinical studies, public health, pharmacology and the biology of disease.
Dr. Christina Papadimitriou and colleagues propose a model showing that everyday care decisions in rehabilitation emerge from relationships between patients, family supporters and clinicians, shaped by wider social forces.
A randomised trial led by Joshua Steinberg at Harvard found that a brief self-guided online program teaching calming skills did not ease anxiety, depression or trauma symptoms in Ukrainian schoolchildren.
Professor David Kaplan's team used a highly sensitive form of flow cytometry to map signalling networks in blood immune cells, revealing distinct patterns in plasma cell disorders and after drug treatment.
In a review, Dr. Andreas Schapowal and colleagues conclude that butterbur leaf extract eases hay fever symptoms about as well as standard allergy drugs without causing drowsiness.
Professor Susan Sharfstein's team reviewed progress in salivary gland bioengineering, from stem cells and gene therapy to bioprinted scaffolds, as possible routes to lasting treatment for dry mouth.
Dr. Vytautas Ostasevicius's team found that low-frequency ultrasound altered hemoglobin and platelet measures in blood samples in the lab, and machine learning could predict the platelet changes.
Jane Siu-Fan Li and colleagues describe a step-by-step laboratory protocol for staining several immune markers at once in tumor tissue, letting researchers map how immune and cancer cells interact.
In a double-blind trial led by Dr. Engelke Marie Randers, minimally invasive sacroiliac joint fusion eased chronic low back pain only slightly more than a sham operation.
In mice with acetaminophen liver injury, Professor Sen-Yung Hsieh's team found that oral fecal transplants enriched butyrate-producing gut bacteria, eased liver damage and improved survival.
Professor Gunda Georg's team found that the oral non-hormonal compound YCT-529 reversibly halted sperm production in male mice and monkeys without changing testosterone, making it a candidate for testing in men.
Dr. Eugene Ng and colleagues created a Sensory Development Care Map guiding when to introduce sound, light and touch for preterm babies, and nurturing time with families rose after its introduction.
Dr. Gábor Somlyai's team reviewed records of Hungarian cancer patients who drank deuterium-depleted water alongside standard treatment and reported survival well above national averages in this real-world data.
