Molecular biology, genetics, microbiology, ecology and animal health.
Dr. Jaffer Ajani's team found that SMARCA4 mutations in gastroesophageal adenocarcinoma did not change patient survival but were linked to particular tumor subtypes, PD-L1 status and other gene mutations.
Dr. Paul Li and Dr. Christopher Oberc used next-generation DNA sequencing and machine-learning clustering on ginseng samples and identified a previously unreported genotype, alongside hybrid samples.
Professor Stephen Bondy argues that failing mitochondria underlie brain aging by driving chronic inflammation, oxidative stress and disrupted nerve signalling, with changes beginning in mid-life.
Dr. Richard Rusk's team found that workers at a Canadian food processing plant using weekly nasal photodisinfection, alongside other safety measures, had lower COVID-19 positivity than regional averages.
Dr. Yu-Chieh David Chen's team describes a protocol that uses genetic crosses instead of microinjection to make gene-specific split-GAL4 lines in fruit flies, lowering cost and complexity.
Professor Dominique Durand's team found that nerve activity recorded inside melanomas in mice could distinguish tumours that spread spontaneously from those with low metastatic potential.
Professor Carol Gregorio's team built Philament, a Python program that automatically tracks moving protein filaments in motility assays, matching manual accuracy while running faster than existing software.
Professor Thomas Look's team found that activated STAT3 works with a small core circuit of transcription factors to keep anaplastic large cell lymphoma cells growing, revealing possible treatment targets.
Professor Bruce Bowerman's team found that microtubules in worm egg cells oppose the actomyosin forces pinching the membrane inward, keeping polar body extrusion balanced during the first meiotic division.
Dr. Ian Rabinowitz's team found that immune, inflammatory and complement genes are strongly switched on in pancreatic cancer tissue compared with normal pancreas, while Malassezia fungus was not linked to tumour growth.
Professor Katarzyna Kwiatkowska's team pinpointed the cysteine where the lipid enzyme DGKε is S-palmitoylated and identified the zDHHC enzymes that attach this fatty acid tag in human cells.
Wolfgang Schmidt and Dharmesh Jain found that Arabidopsis plants grow best at moderately acidic pH and adjust to acidic or alkaline conditions largely through changes in protein phosphorylation.
