The Key to Cholangiocarcinoma Treatment Lies in SERPINE1
Professor Paul Higgins's team reviewed evidence that the protein made by the SERPINE1 gene helps bile duct cancer grow and resist treatment within the dense tissue around tumours.
Field
Life Sciences
Molecular biology, genetics, microbiology, ecology and animal health.
Critical Enzyme Found Essential for Embryo Implantation
Dr. Maria Laura Zenclussen's team found that silencing the enzyme HO-1 stopped trophoblast spheroids attaching to womb-lining cells, which carbon monoxide reversed, and HO-1-deficient mice showed disrupted uterine genes.
Schooling Fish Show Light-Driven Changes in Collective Behavior
Dr. Guy Theraulaz's team found that light intensity tunes the strength and range of social interactions in rummy-nose tetras, shifting how their schools move as a group.
New Insights into Complement Proteins and Immune Cell Interactions
Giuseppe Barile's laboratory work shows that complement protein fragments attach to the CR2 receptor on immune cells through mechanisms shaped by hydrophobic aromatic residues in the C3c structure.
Targeting Tips for Treating Pseudomonas aeruginosa Infections in Cystic Fibrosis – Look to Sugars for a Key
Dr. Deborah Chance's team found that Pseudomonas aeruginosa strains from cystic fibrosis and other sources bound the same specific sugars, pointing to possible targets for anti-adhesive therapies.
The Mystery of Cell Channels and Their Two-Way Communication Gates
Professor Camillo Peracchia describes how gap junction channels between cells are controlled by a slow calmodulin-based chemical gate and a faster, partial voltage-sensitive gate.
Fibonacci Sequences Unveil the Symmetries of the Genetic Code
Professor Tidjani Négadi used Fibonacci-like number sequences to reveal symmetries in the genetic code that persist even when amino acids are in their charged, physiological state.
Recombinant Proteins Show Promise for Osteoporosis Treatment
Professor Mari Cleide Sogayar's team found that injecting the recombinant growth factors BMP-7 and PDGF-BB partially reversed bone loss in rats with surgically induced osteoporosis.
The 3Rs in Respiratory Research: combination of methods is key
Professor Eleonore Fröhlich reviews how animal models used in respiratory research differ from humans and argues that combining laboratory methods with targeted animal testing works best.
Genetic Profiling Reveals Immunotherapy Potential for Rare Head and Neck Cancer
Dr. Yoshihito Kano's team found that immune checkpoint drugs helped only some patients with adenoid cystic carcinoma of the head and neck, and MYB gene changes may flag better responders.
Enhanced HCP Monitoring Platform Sets New Industry Standard
Elisa Giordano's team developed an in-house assay for host cell protein impurities in drug production that proved more sensitive and specific than commercial kits, especially in later development.
PIEZO1 Found to Hinder Wound Healing Process
Professor John Lowengrub's team found that the ion channel PIEZO1 suppresses the leader cells that guide skin cells across a wound, slowing coordinated closure in experiments and simulations.