Features based on peer-reviewed papers published in International Journal of Molecular Sciences.
Professor Aleksandar Ljubić's team reviews early evidence that combining mesenchymal and blood-forming stem cells may help restore ovarian function in premature ovarian insufficiency, while stressing safety risks.
Professor Alika Maunakea's team reviews how gut microbes and their products, such as short-chain fatty acids, may reshape human gene regulation through DNA and RNA methylation, affecting immunity and disease risk.
In laboratory and computer tests, a team led by Dr. Meixia Yang and Professor Karl Tsim found that gyrophoric acid, a lichen compound, blocks and breaks up amyloid-beta clumps linked to Alzheimer's.
Using experiments and simulations, Dr. Gonzalo Izaguirre identified an internal lock in antithrombin that keeps it inactive until heparin binds, suggesting routes to anticoagulants less reliant on heparin.
Dr. Nevena Puač's team found that plasma-activated water helped wounds heal faster in diabetic rats, mainly by calming inflammation and preserving collagen, without changing blood sugar.
In a review, Dr. Jiro Takito and Dr. Naoko Nonaka propose that waves of the protein actin are a shared principle by which immune cells and bone-resorbing cells build dynamic structures.
Dr. Esther Natalie Oliva's team found that older patients with acute myeloid leukemia given azacitidine after remission stayed in remission longer, and linked certain gene mutations to higher relapse risk.
Dr. Sofia Gitler's team found that in rats with chronic heart failure, skeletal muscle kept its strength while proteins handling calcium and glucose rose sharply in muscle membranes.
Professor Franz Sellner's team reviewed evidence that isolated pancreatic metastases of clear-cell kidney cancer carry a distinct, less aggressive genetic profile, though the cases remain few.
Professor Katrin Mani's team found that the protein Glypican-4 tracks with worse outcomes in glioblastoma but better survival in lung adenocarcinoma, and switching it off had opposite effects.
Professor Camillo Peracchia describes how gap junction channels between cells are controlled by a slow calmodulin-based chemical gate and a faster, partial voltage-sensitive gate.
Professor Eleonore Fröhlich reviews how animal models used in respiratory research differ from humans and argues that combining laboratory methods with targeted animal testing works best.
