Embarking on what seems like a straightforward medical procedure, only to be thrust into an unending cycle of health complications, is a narrative few can imagine. Yet, this is the reality for those grappling with a condition as elusive as it is rare: parathyromatosis. This disorder emerges in the aftermath of routine surgery, evolving into a formidable adversary that challenges the limits of medical intervention. The tale weaves together the fates of determined doctors and a patient whose resilience shines amidst continuous trials. Through this story, the complexity of a scarcely seen medical condition is illuminated, showcasing the indomitable spirit of those facing it head-on.

At the helm of groundbreaking research into this rare condition is Dr. Mansoor Alramadhan and his team at King Saud Medical City, including Modhi Hamad Alawadh, Nada Abdulaziz Bin Samaih, and Abdulsalam Aodah, with contributions from Rania Abdullah Alshammari of King Khalid General Hospital and independent researcher Shada Khaled Bashantoof. Together, they delve into the world of parathyromatosis, a disorder marked by its rarity and the significant challenges it presents to both the affected individuals and their healthcare providers. Detailed in the International Journal of Surgery Case Reports, their study brings to light the relentless struggle against recurrent hyperparathyroidism that persists despite numerous attempts at surgical resolution over two decades.

Parathyromatosis is characterized by the return of overactive parathyroid gland function following the removal of the parathyroid gland. This condition highlights the challenges in controlling persistent hyperparathyroidism, often resulting from the accidental spread of parathyroid gland tissue after surgery.

The story unfolds in 2003 when a young woman of 18 sought treatment for pain in her lower limbs, leading to the discovery of a parathyroid cyst. An unintended rupture of this cyst during its removal seeded the area with its contents, setting off a chain of events characterized by repeated episodes of hyperparathyroidism. Over the ensuing twenty years, she would face numerous surgeries in hope of finding lasting relief.

The roots of parathyromatosis are varied, with speculation ranging from surgical mishaps that lead to the spread of glandular tissue to the possibility of genetically altered parathyroid glands taking hold. This multifaceted nature is reflected in the patient’s ongoing struggle, which includes battling frequent bone weakening and kidney stones.

Achieving a permanent solution remained elusive despite the medical team’s extensive efforts. Following each surgical attempt to alleviate her symptoms, the disease made a comeback, underscoring parathyromatosis’s stubborn persistence and the complexity of completely removing it. Dr. Alramadhan explained, “Diagnosing parathyromatosis is a complex task that involves distinguishing it from similar gland issues; successful management requires thorough removal of all affected tissue, with the understanding that recurrence is a real possibility necessitating further surgeries.”

This narrative serves as a testament to the intricacies of diagnosing and managing rare health conditions such as parathyromatosis. It emphasizes the importance of precise surgical techniques, well-rounded medical treatment, and the critical role of ongoing patient education and care. Dr. Alramadhan adds, “The occurrence of primary hyperparathyroidism varies, with a significant majority caused by a single adenoma, and only a fraction resulting from parathyroid cancer. Managing such an uncommon condition poses substantial challenges in both diagnosis and treatment, often requiring a combination of medical and surgical interventions, and is further complicated by various theories regarding its origin.”

As illustrated by this patient’s journey, navigating the path to managing parathyromatosis is fraught with challenges, demanding resilience, patience, and a committed medical team eager to explore every possible avenue to provide relief and enhance the lives of those impacted. The ongoing fight against parathyromatosis symbolizes the broader struggles encountered in rare disease management. It serves as a reminder of the continuous need for research, innovation, and a collaborative approach to healthcare, ensuring that future patients with similar diagnoses can look forward to a future filled with hope and improved health.


Shada Khaled Bashantoof, Mansoor Abdulmajeed Alramadhan, Modhi Hamad Alawadh, Nada Abdulaziz Bin Samaih, Rania Abdullah Alshammari, Abdulsalam Aodah, Intractable Parathyromatosis despite extensive surgical interventions: A case report with literature review, International Journal of Surgery Case Reports, Volume 114, 2024,109172.

DOI: https://doi.org/10.1016/j.ijscr.2023.109172.


Shada Bashantoof, a third year General Surgery resident in Riyadh Cluster One at Kingdome of Saudi Arabia, graduated from medical collage at University of Hail with an honor degree in 2020, I had contributed and published multiple researches in surgical field in which I become a skilled writer and effective teammate.

I had the opportunity to participate in multiple surgical symposiums with oral and poster presentations.

Interested in health & community volunteering, researches and invention in which won multiple awards. Working with passion in general surgery with a goal of becoming a safe surgeon and research impactor.

Mansoor Alramadhan, MD

Consultant general, breast & endocrine surgical oncology

Interested in the management of thyroid, parathyroid and breast diseases. Working in king Saud Medical City, Riyadh, Saudi Arabia.