Clinical studies, public health, pharmacology and the biology of disease.
Dr. Sanjive Qazi's team found that children with diffuse midline glioma whose tumours showed high TGFB2 and low IFNGR2 activity had significantly worse overall survival.
Professor Heinz Steiner's team found that the antidepressant vilazodone suppressed involuntary movements caused by levodopa in a rat model of Parkinson's disease without blunting levodopa's motor benefits.
Dr. Rumela Chakrabarti's team found that the protein ΔNp63 helps triple-negative breast cancer suppress immunity in mice, and the HDAC inhibitor Quisinostat lowered it, slowing tumour growth and spread.
Professor Yingbin Fu's team reviews why some macular degeneration patients stop responding to anti-VEGF drugs, and a combination approach targeting macrophages that showed promise in animals.
Dr. John Michael Bryant and colleagues review how MRI-guided linear accelerators let clinicians adapt radiotherapy for brain and spine tumours to daily changes in anatomy.
Dr. Isabelle Thierry-Chef's team has laid out a plan to compare how X-ray and CT scanners are available and used to diagnose tuberculosis in children in Mozambique, South Africa and Spain.
Dr. Paula Johnson's team found that people with a history of repetitive head impacts showed better reaction time, grip strength and balance after a course of near-infrared light therapy.
Professor Michael Ross's team found that breastfeeding mothers with overweight or obesity produced higher-fat, higher-calorie milk, with milk fat tracking their blood triglyceride and insulin levels.
Dr. Georges Maestroni reviews evidence that melatonin can strengthen immune responses and curb inflammation in infections, while noting that clinical results so far are mixed.
Dr. Mohammed Shahait's team reviewed evidence that diabetes drugs called GLP-1 receptor agonists may curb prostate cancer cell growth, noting that support so far comes mainly from preclinical studies.
Dr. Ingo Schmidt reports a patient whose locking-screw wrist implant stayed firmly fixed for years despite bone graft death around it, suggesting locking screws may help such implants last.
Professor Alfredo Franco-Obregón's team found that brief magnetic pulses prompt muscle cells to release secretions that curb breast cancer cell growth and invasion, an effect that depends on the protein HTRA1.
