Clinical studies, public health, pharmacology and the biology of disease.
Dr. Viktor Wixler's team found that small spleen peptides push dendritic cells toward a tolerance-promoting state by reshaping ATP signaling outside cells, and eased psoriatic skin inflammation in mice.
Dr. Xiaoping Ren's team reviews spinal cord fusion, in which severed spinal cord ends are rejoined with polyethylene glycol and electrical stimulation, and its promising results in animal studies.
Professor Giulia Marchetti's team found that unvaccinated people with HIV hospitalised with COVID-19 had more virus in their blood, skewed T-cell responses and stronger inflammation than others.
Professor Barry Popkin's team compared ways of combining processing and nutrient criteria, giving policymakers a simpler method to flag foods that are ultra-processed and high in salt, sugar or fat.
Professor Stelios Andreadis's team found that adding the amino acid proline to aged stem cells restored mitochondrial function and mitophagy and reduced several markers of cellular aging.
Professor Andrew Harman's review explains that dendritic cells, not only Langerhans cells, capture viruses in skin and mucosal linings, with implications for designing vaccines that work at these surfaces.
Dr. Jungsun Kim's team found that Sendai virus delivered genes into pancreatic cancer cells of different subtypes more efficiently and consistently than other commonly used viral vectors.
Professor Jerilynn Prior's pilot diary study found that women with PCOS had menstrual cycles and moods much like controls during the early pandemic, but reported more outside stress.
Dr. Wenbin Qian's team found that off-the-shelf CAR-engineered double-negative T cells were well tolerated in an early trial for relapsed large B-cell lymphoma, with promising responses at higher doses.
Dr. Daniel Tanure's team describes a young girl whose swallowed ball magnets linked together inside her bowel and perforated it, requiring surgery to remove them.
Professor Rasoul Salehi's team reviews cell-based approaches for type 1 diabetes, highlighting beta-cell transcription factors as a direct route to making insulin-producing cells from stem cells.
Dr. Dongrui Zhou's team found that feeding sterilized soil to mice with induced asthma shifted their gut bacteria and reduced inflammatory signals linked to allergic asthma.
