Clinical studies, public health, pharmacology and the biology of disease.
Dr. Felix Pabon-Rodriguez's team built a Bayesian model that links parasite load and immune responses to disease progression and death in dogs naturally exposed to Leishmania.
Dr. Francis Lai and colleagues summarize a psoriasis symposium that covered the disease's genetic history, immune mechanisms, big data and moves toward personalized, holistic treatment.
Professor Heinz Steiner's team found in rats that, unlike fluoxetine, the antidepressant vilazodone does not amplify methylphenidate's effects on gene regulation in the striatum.
Dr. Long-Cheng Li's team found that a new gene-silencing therapy injected into the spinal fluid delayed disease, extended survival and protected motor function in a mouse model of ALS.
Dr. Engelke Marie Randers's team found that minimally invasive sacroiliac joint fusion relieved pain only slightly more than a sham operation in a double-blind randomised trial.
Dr. Normaliza Ab Malik and Professor Angus Walls reviewed case-control studies and found that people with dementia or Alzheimer's disease generally had poorer gum health than healthy controls.
In a career retrospective, Dr. Martha Welch describes evidence that oxytocin acts in the gut and body as well as the brain, alongside her trials of a family intervention for premature infants.
Professor Natalia Jimeno's narrative review maps assessment tools and rehabilitation therapies for the language and communication problems of schizophrenia, from broad cognitive programmes to targeted pragmatic training.
Dr. Moutih Rafei's team found that treating mesenchymal stromal cells with an Accum variant turned them into antigen-presenting cells that triggered strong anti-tumour responses in mice.
Dr. Alexander Chumanevich's team found that the food dye Red 40 damaged DNA, inflamed the colon and altered gut microbes in mice.
Dr. Asmita Dawadi's team found that lip repositioning surgery reduced gum display in patients with gummy smiles and lowered their anxiety about their appearance months after surgery.
Peiguan Huang and Dr. Xiaojun Tang describe a 'mini-incision' arthroscopic technique for repairing partial supraspinatus tendon tears that aims to limit tendon trauma while reattaching it anatomically.
