Clinical studies, public health, pharmacology and the biology of disease.
Professor Rachel Golub's team found in mice that, during fatty liver inflammation, activated bone marrow monocytes boost production of natural killer cells, which then travel to the liver and slow scarring.
Professor Upender Manne's team found that blocking the protein TRIP13, genetically or with the inhibitor DCZ0415, reduced pancreatic cancer cell growth, invasion and spread in laboratory experiments.
Professor Xueding Wang's team found that combining low-energy laser pulses with ultrasound bursts selectively destroyed excess skin blood vessels in chicken wattles without damaging surrounding collagen.
Professor Tilman Steinert's team found that helping German psychiatric wards follow guidelines on preventing coercion improved adherence but did not significantly reduce how often coercive measures were used.
Professor David Rubin and colleagues developed a machine learning model that reads endoscopy videos to predict the Mayo endoscopic score, accurately separating active from inactive ulcerative colitis.
Dr. Amanda Craig's team mapped transcription factor activity in single cells from liver tumors, finding factors that separate the two main liver cancer types and linking POU activity to poorer survival.
Professor Andrzej Grzybowski's team found that photodynamic therapy cleared fluid under the retina in most eyes with chronic central serous chorioretinopathy after micropulse laser treatment had failed.
Interviews by Professor Jennifer Warren's team found that low-income women at Planned Parenthood were receptive to a digital HPV education kiosk, QR codes and vaccine reminder texts.
Dr. Tomoki Kuwahara's team found that lysosomal stress drives immune cells of the macrophage lineage to release harmful α-synuclein through the LRRK2-Rab10 pathway.
Dr. Hyungjin Kim's team found that Veterans Health Administration behavioural health providers with more say over whether they teleworked during the pandemic reported less burnout.
Dr. Katsuhiko Oda's team describes patients whose AFX endografts shortened and migrated years after aneurysm repair, and advises caution when the graft's main body is likely to angle.
Dr. Graham Adams and Dr. Philip O'Brien propose a unified theory tracing the origin of sleep to the ancient endosymbiotic partnership that gave rise to mitochondria.
