Anemia is a widespread health issue, especially among children and women of reproductive age. Despite advances in medicine, many treatments for anemia fall short due to problems like poor absorption of iron supplements, unpleasant side effects, and the need for daily doses that can be hard to stick to. Imagine a simple patch you could wear that delivers the necessary iron directly into your body, painlessly and effectively, over several days—making treatment easier and more reliable for millions of people.
Researchers from the Dr. Reddy’s Institute of Life Sciences, Hyderabad, led by Dr. Marina Rajadurai, along with Professor Parimal Misra, Bhavya Surekha and Aiswarya Madathil, have developed a novel transdermal patch loaded with iron(II) nanoparticles that offers a promising solution for combating iron deficiency anemia. This innovative patch, published in the Materials Advances journal, utilizes microneedles to deliver iron directly through the skin, bypassing the gastrointestinal system, which often leads to poor absorption and significant side effects in conventional oral iron supplements.
Iron deficiency anemia remains a critical global health issue, particularly affecting children and women of reproductive age. Current treatments face significant challenges, including low bioavailability of oral iron supplements, unpleasant side effects, and issues with patient compliance. The research team sought to address these problems by designing a biodegradable patch that not only provides sustained iron release over an extended period but also minimizes the initial burst of iron that can cause adverse reactions.
The microneedles, made from a biodegradable polymer, are embedded with iron sulfate nanoparticles (IS NPs) and are designed to release iron in a controlled manner for nearly two weeks. The microneedles are small yet effective for painless transdermal delivery without causing significant discomfort to the user.
In vitro testing of the patch showed that it achieves the majority of its drug release over the full duration, with the release during the first several hours following a near-linear pattern. Notably, the initial burst release of iron, often a challenge in similar delivery systems, was kept low when tested on porcine skin models. This controlled release is crucial for ensuring that patients receive a steady dose of iron without experiencing the spikes that can lead to gastrointestinal issues.
Dr. M. Rajadurai emphasized the importance of this innovation, stating, “Our microneedle patch represents a significant advancement in the treatment of iron deficiency anemia. By providing a sustained and controlled release of iron, we aim to improve patient outcomes and reduce the burden of this condition globally.”
The study also included an acceptance survey conducted by Dr. Anitha C. Thippaiah, and Prof. Bindiganavale R. Shamanna among healthcare professionals and potential beneficiaries. The survey revealed that the patch was well-received, particularly among urban residents and healthcare providers, who recognized its potential to improve compliance and effectiveness in anemia treatment. However, the survey also highlighted the need for additional education and outreach in rural areas, where traditional methods of iron supplementation are more commonly accepted.
Looking forward, the research team plans to conduct in vivo studies to further evaluate the efficacy and safety of the patch. These studies will be crucial in determining the patch’s potential for widespread clinical use and could pave the way for a new standard in anemia treatment, particularly in regions where adherence to oral supplements is a significant challenge.
In conclusion, Dr. Rajadurai and her colleagues’ innovative microneedle patch loaded with iron(II) nanoparticles offers a promising new approach to managing iron deficiency anemia. By addressing the shortcomings of current treatments, their work has the potential to improve the quality of life for millions of people worldwide who suffer from this condition.
Journal Reference
Bhavya Surekha, Parimal Misra, Anitha C. Thippaiah, Bindiganavale R. Shamanna, Aiswarya Madathil, Marina Rajadurai. “A microneedle transdermal patch loaded with iron(ii) nanoparticles for non-invasive sustained delivery to combat anemia.” Materials Advances (2024). DOI: https://doi.org/10.1039/D3MA01166F
About the Author
Dr. Marina Rajadurai earned her M.Sc. degree in Chemistry in 1998 from D.I. Mendeleev Russian Chemical-Technological University, Moscow, Russia. She then worked as an Engineer for four years at the A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia, before joining the PhD program at the same institute. In 2006, she completed her PhD, during which she also spent time as a Visiting Graduate Student at the Max Planck Institute for Polymer Research, Mainz, Germany.
In 2008, Dr. Rajadurai became a Postdoctoral Fellow at the Institute of Life Sciences, Hyderabad, where her research focused on Medicinal Chemistry and the design of novel fluorescent nanomaterials for biological imaging. In 2010, she was appointed as a scientist at Dr. Reddy’s Institute of Life Sciences, Hyderabad, where she continues to work today as Assoc. Principal Research Scientist.
Dr. Rajadurai’s current research is centered on the development of nanoparticle-based drug delivery systems. She employs innovative approaches to create efficient and potent drug delivery mechanisms, including microneedle technology, lipid nanoparticles, and hydrogel nano- and microparticles. A key focus of her work is controlling the morphology and dimensions of bioactive compounds at the nano- and sub-micro levels to enhance their biological activities. Her group is dedicated to finding innovative solutions to address existing challenges in drug resistance and nutrient deficiency.
